' 
SCIENTIFIC SCORE
Moderately Effective
Based on 9 Researches
8.1
USERS' SCORE
Good
Based on 2 Reviews
8.5
Supplement Facts
Serving Size: 2 Capsules
Amount Per Serving
%DV
Total Carbohydrate
<1g
<1%†
Calcium (from calcium magnesium phytate)
131 mg
10%
Phosphorus (from calcium magnesium phytate)
192 mg
15%
Magnesium (from calcium magnesium phytate)
40 mg
10%
IP-6 (inositol hexaphosphate) (from calcium magnesium phytate)
800 mg
**
Inositol
220 mg
**
Maitake Mushroom Extract standardized to 30% pure D-fraction (9 mg)
30 mg
**
Cat's Claw Extract (bark) standardized to 4% alkaloids (0.4 mg)
10 mg
**
Top Medical Research Studies
9
Maitake improves diabetes-related liver health
Anti-diabetic effect of an alpha-glucan from fruit body of maitake (Grifola frondosa) on KK-Ay mice.
Highly relevant to liver function
We evaluated the impact of an alpha-glucan extracted from maitake mushrooms on mice with a model of type 2 diabetes. This study specifically focused on various health markers related to liver function and diabetes.
By administering two different doses of the maitake mushroom extract, we observed significant improvements across several measures in diabetic mice. The treatment led to reductions in body weight, fasting blood sugar levels, and harmful substances like triglycerides and cholesterol.
Notably, we found that liver functions improved as evidenced by increased levels of beneficial substances like glycogen and reduced oxidative stress markers. Additionally, we observed enhanced insulin sensitivity, which is crucial for managing diabetes effectively.
These findings suggest that maitake mushrooms may offer tangible benefits not only for diabetes management but specifically for protecting and improving liver health in affected individuals.
By administering two different doses of the maitake mushroom extract, we observed significant improvements across several measures in diabetic mice. The treatment led to reductions in body weight, fasting blood sugar levels, and harmful substances like triglycerides and cholesterol.
Notably, we found that liver functions improved as evidenced by increased levels of beneficial substances like glycogen and reduced oxidative stress markers. Additionally, we observed enhanced insulin sensitivity, which is crucial for managing diabetes effectively.
These findings suggest that maitake mushrooms may offer tangible benefits not only for diabetes management but specifically for protecting and improving liver health in affected individuals.
Read More
9
Cat's claw benefits liver health
Uncaria tomentosa improves insulin sensitivity and inflammation in experimental NAFLD.
High relevance to liver disease study
We explored the effects of Uncaria tomentosa, commonly known as cat's claw, on non-alcoholic fatty liver disease (NAFLD) in two different models of obesity: mice on a high-fat diet and genetically obese mice. Both groups were experiencing insulin resistance, along with noticeable liver issues such as an excess of fat and inflammation.
The results were promising. Cat's claw treatment led to significant reductions in liver fat and inflammation across both mouse models. We observed that in the high-fat diet group, serine phosphorylation of the protein IRS-1 decreased by 25% with cat's claw treatment, which is a positive sign of enhanced insulin sensitivity.
Overall, we found that the cat's claw extract improved blood sugar control and helped to revert NAFLD to a healthier state, accompanied by reduced liver inflammation. This suggests a beneficial potential for cat's claw in tackling liver-related complications often associated with obesity.
The results were promising. Cat's claw treatment led to significant reductions in liver fat and inflammation across both mouse models. We observed that in the high-fat diet group, serine phosphorylation of the protein IRS-1 decreased by 25% with cat's claw treatment, which is a positive sign of enhanced insulin sensitivity.
Overall, we found that the cat's claw extract improved blood sugar control and helped to revert NAFLD to a healthier state, accompanied by reduced liver inflammation. This suggests a beneficial potential for cat's claw in tackling liver-related complications often associated with obesity.
Read More
8
Myo-inositol improves insulin resistance
The effect of myo-inositol supplementation on AMPK/PI3K/AKT pathway and insulin resistance in patients with NAFLD.
Significant findings for IR management
We conducted a double-blinded, placebo-controlled clinical trial to explore how myo-inositol (MI) influences insulin resistance (IR) among obese individuals with non-alcoholic fatty liver disease (NAFLD). Our study involved 48 participants who were randomly assigned to receive either 4 grams of MI or a placebo daily for eight weeks.
Throughout this period, we measured various parameters such as weight, serum glucose levels, and insulin sensitivity indices before and after the intervention. Notably, we found that MI supplementation led to significant improvements in the expression levels of key genes related to the AMPK/PI3K/AKT signaling pathway, which plays a crucial role in regulating metabolism.
The results indicated noteworthy enhancements in insulin resistance for those who received MI, measured through multiple indices, reinforcing its potential benefits for liver health management. Thus, we observed that supplementing with myo-inositol not only bolstered the expression of important metabolic genes but also helped improve insulin resistance in our participants with NAFLD.
Throughout this period, we measured various parameters such as weight, serum glucose levels, and insulin sensitivity indices before and after the intervention. Notably, we found that MI supplementation led to significant improvements in the expression levels of key genes related to the AMPK/PI3K/AKT signaling pathway, which plays a crucial role in regulating metabolism.
The results indicated noteworthy enhancements in insulin resistance for those who received MI, measured through multiple indices, reinforcing its potential benefits for liver health management. Thus, we observed that supplementing with myo-inositol not only bolstered the expression of important metabolic genes but also helped improve insulin resistance in our participants with NAFLD.
Read More
Most Useful Reviews
8.8
Ferritin reduction
I initially used Nature's Way products for high ferritin levels, which were concerning due to my fatty liver. After two months on the product, my ferritin significantly decreased, and my liver function tests also improved, surprising me. I later tried IP6 Gold, but the decrease in ferritin became much slower. I plan to return to Nature's Way to see if the results can be replicated.
Read More
8
Tumour shrinkage
I have found Cell Forte Max3, formerly known as IP-6, to be remarkably effective. I've used it for my toxic mold exposure and observed similar benefits in animals with liver disease and other serious conditions. After a month on this product, a small fatty tumour shrank significantly, illustrating its potential. Given its safety profile, there's no fear of overdosing, and I highly recommend it based on my experiences since 1990.
Read More
Medical Researches
SCIENTIFIC SCORE
Moderately Effective
Based on 9 Researches
8.1
- All Researches
9
Maitake improves diabetes-related liver health
Anti-diabetic effect of an alpha-glucan from fruit body of maitake (Grifola frondosa) on KK-Ay mice.
Highly relevant to liver function
We evaluated the impact of an alpha-glucan extracted from maitake mushrooms on mice with a model of type 2 diabetes. This study specifically focused on various health markers related to liver function and diabetes.
By administering two different doses of the maitake mushroom extract, we observed significant improvements across several measures in diabetic mice. The treatment led to reductions in body weight, fasting blood sugar levels, and harmful substances like triglycerides and cholesterol.
Notably, we found that liver functions improved as evidenced by increased levels of beneficial substances like glycogen and reduced oxidative stress markers. Additionally, we observed enhanced insulin sensitivity, which is crucial for managing diabetes effectively.
These findings suggest that maitake mushrooms may offer tangible benefits not only for diabetes management but specifically for protecting and improving liver health in affected individuals.
By administering two different doses of the maitake mushroom extract, we observed significant improvements across several measures in diabetic mice. The treatment led to reductions in body weight, fasting blood sugar levels, and harmful substances like triglycerides and cholesterol.
Notably, we found that liver functions improved as evidenced by increased levels of beneficial substances like glycogen and reduced oxidative stress markers. Additionally, we observed enhanced insulin sensitivity, which is crucial for managing diabetes effectively.
These findings suggest that maitake mushrooms may offer tangible benefits not only for diabetes management but specifically for protecting and improving liver health in affected individuals.
Read More
9
Cat's claw benefits liver health
Uncaria tomentosa improves insulin sensitivity and inflammation in experimental NAFLD.
High relevance to liver disease study
We explored the effects of Uncaria tomentosa, commonly known as cat's claw, on non-alcoholic fatty liver disease (NAFLD) in two different models of obesity: mice on a high-fat diet and genetically obese mice. Both groups were experiencing insulin resistance, along with noticeable liver issues such as an excess of fat and inflammation.
The results were promising. Cat's claw treatment led to significant reductions in liver fat and inflammation across both mouse models. We observed that in the high-fat diet group, serine phosphorylation of the protein IRS-1 decreased by 25% with cat's claw treatment, which is a positive sign of enhanced insulin sensitivity.
Overall, we found that the cat's claw extract improved blood sugar control and helped to revert NAFLD to a healthier state, accompanied by reduced liver inflammation. This suggests a beneficial potential for cat's claw in tackling liver-related complications often associated with obesity.
The results were promising. Cat's claw treatment led to significant reductions in liver fat and inflammation across both mouse models. We observed that in the high-fat diet group, serine phosphorylation of the protein IRS-1 decreased by 25% with cat's claw treatment, which is a positive sign of enhanced insulin sensitivity.
Overall, we found that the cat's claw extract improved blood sugar control and helped to revert NAFLD to a healthier state, accompanied by reduced liver inflammation. This suggests a beneficial potential for cat's claw in tackling liver-related complications often associated with obesity.
Read More
8
Myo-inositol improves insulin resistance
The effect of myo-inositol supplementation on AMPK/PI3K/AKT pathway and insulin resistance in patients with NAFLD.
Significant findings for IR management
We conducted a double-blinded, placebo-controlled clinical trial to explore how myo-inositol (MI) influences insulin resistance (IR) among obese individuals with non-alcoholic fatty liver disease (NAFLD). Our study involved 48 participants who were randomly assigned to receive either 4 grams of MI or a placebo daily for eight weeks.
Throughout this period, we measured various parameters such as weight, serum glucose levels, and insulin sensitivity indices before and after the intervention. Notably, we found that MI supplementation led to significant improvements in the expression levels of key genes related to the AMPK/PI3K/AKT signaling pathway, which plays a crucial role in regulating metabolism.
The results indicated noteworthy enhancements in insulin resistance for those who received MI, measured through multiple indices, reinforcing its potential benefits for liver health management. Thus, we observed that supplementing with myo-inositol not only bolstered the expression of important metabolic genes but also helped improve insulin resistance in our participants with NAFLD.
Throughout this period, we measured various parameters such as weight, serum glucose levels, and insulin sensitivity indices before and after the intervention. Notably, we found that MI supplementation led to significant improvements in the expression levels of key genes related to the AMPK/PI3K/AKT signaling pathway, which plays a crucial role in regulating metabolism.
The results indicated noteworthy enhancements in insulin resistance for those who received MI, measured through multiple indices, reinforcing its potential benefits for liver health management. Thus, we observed that supplementing with myo-inositol not only bolstered the expression of important metabolic genes but also helped improve insulin resistance in our participants with NAFLD.
Read More
8
Maitake extract shows liver benefits
Application of the thick extract from Maitake mushrooms for correction of metabolic disorders under the paracetamol hepatitis in rats.
Moderate relevance due to comparison
We explored the potential of Maitake mushroom extract as a treatment for liver disease, specifically in cases of paracetamol-induced hepatitis in rats. The study involved a controlled experiment with 60 male rats, split into groups to assess the effects of the mushroom extract against a comparison drug known as Silibor.
For the tests, rats were given a significant dose of acetaminophen to induce liver damage. This was followed by administering the thick extract of Maitake mushrooms to see if it could help mitigate the damage. We observed that the extract was given before and after the toxic treatment to evaluate its potential protective properties.
Our findings indicated that the Maitake mushroom extract showed promising effects by exhibiting hepatoprotective, cytoprotective, and antioxidative properties. This suggests that it may indeed offer a beneficial approach to supporting liver health during acute damage caused by toxins. While more research is necessary to understand its effectiveness fully, this study highlights the value of natural substances like Maitake mushrooms in liver disease treatment.
For the tests, rats were given a significant dose of acetaminophen to induce liver damage. This was followed by administering the thick extract of Maitake mushrooms to see if it could help mitigate the damage. We observed that the extract was given before and after the toxic treatment to evaluate its potential protective properties.
Our findings indicated that the Maitake mushroom extract showed promising effects by exhibiting hepatoprotective, cytoprotective, and antioxidative properties. This suggests that it may indeed offer a beneficial approach to supporting liver health during acute damage caused by toxins. While more research is necessary to understand its effectiveness fully, this study highlights the value of natural substances like Maitake mushrooms in liver disease treatment.
Read More
8
Maitake beneficial against liver cancer
Synergistic Apoptotic Effect of D-Fraction From Grifola frondosa and Vitamin C on Hepatocellular Carcinoma SMMC-7721 Cells.
Mushroom's effects on liver cancer
We examined the effects of a combination of D-fraction polysaccharide from the maitake mushroom and vitamin C on liver cancer cells in a lab setting. The goal was to find out whether this mix could effectively reduce the growth of hepatocellular carcinoma, a common type of liver cancer.
Our experiments included various concentrations of the mushroom extract and vitamin C to test their anticancer properties against the SMMC-7721 liver cancer cell line. We discovered that when we combined 0.2 mg/mL of the D-fraction extract with 0.3 mmol/L of vitamin C, there was a notable 70% reduction in the cancer cells' viability.
Additionally, we found that about 65% of these cells underwent apoptosis, or programmed cell death, after treatment. This suggests that the combination not only halted the cancer cells' ability to divide but also pushed many of them toward self-destruction. Observations made using electron microscopy revealed significant changes in the cell structure following treatment, further supporting the effectiveness of this combination.
In our analysis of the mechanism behind these effects, we noted key protein changes that indicated the activation of the apoptosis process, showing that this combination may offer a promising avenue for future liver cancer therapies.
Our experiments included various concentrations of the mushroom extract and vitamin C to test their anticancer properties against the SMMC-7721 liver cancer cell line. We discovered that when we combined 0.2 mg/mL of the D-fraction extract with 0.3 mmol/L of vitamin C, there was a notable 70% reduction in the cancer cells' viability.
Additionally, we found that about 65% of these cells underwent apoptosis, or programmed cell death, after treatment. This suggests that the combination not only halted the cancer cells' ability to divide but also pushed many of them toward self-destruction. Observations made using electron microscopy revealed significant changes in the cell structure following treatment, further supporting the effectiveness of this combination.
In our analysis of the mechanism behind these effects, we noted key protein changes that indicated the activation of the apoptosis process, showing that this combination may offer a promising avenue for future liver cancer therapies.
Read More
User Reviews
USERS' SCORE
Good
Based on 2 Reviews
8.5
- All Reviews
- Positive Reviews
- Negative Reviews
8.8
Ferritin reduction
I initially used Nature's Way products for high ferritin levels, which were concerning due to my fatty liver. After two months on the product, my ferritin significantly decreased, and my liver function tests also improved, surprising me. I later tried IP6 Gold, but the decrease in ferritin became much slower. I plan to return to Nature's Way to see if the results can be replicated.
Read More
8
Tumour shrinkage
I have found Cell Forte Max3, formerly known as IP-6, to be remarkably effective. I've used it for my toxic mold exposure and observed similar benefits in animals with liver disease and other serious conditions. After a month on this product, a small fatty tumour shrank significantly, illustrating its potential. Given its safety profile, there's no fear of overdosing, and I highly recommend it based on my experiences since 1990.
Read More
